Bioorganic and Medicinal Chemistry Letters p. 841 - 846 (2018)
Update date:2022-07-30
Topics:
Winters, Michael P.
Sui, Zhihua
Wall, Mark
Wang, Yuanping
Gunnet, Joseph
Leonard, James
Hua, Hong
Yan, Wen
Suckow, Arthur
Bell, Austin
Clapper, Wilmelenne
Jenkinson, Celia
Haug, Peter
Koudriakova, Tatiana
Huebert, Norman
Murray, William V.
The discovery of a novel series of N-arylpyrroles as agonists of GPR120 (FFAR4) is discussed. One lead compound is a potent GPR120 agonist, has good selectivity for related receptor GPR40 (FFAR1), has acceptable PK properties, and is active in 2 models of Type 2 Diabetes in mice.
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