Synthesis, resolution and assignment of absolute configuration of 2-(α-hydroxy)aryl acrylate esters

Article abstract of DOI:10.1016/S0957-4166(00)80204-9

(-)(R,R)-2-Amino-1-(4-nitrophenyl)propan-1,3-diol 3 has been used to resolve racemic 3-hydroxy-2-methylene-3-phenylpropanoic acid 1a. Conversion of the laevorotatory enantiomer into anti and syn methyl 3-hydroxy-2-methyl-3-phenypropanoate, 2a and 2b respe