Chemistry of Heterocyclic Compounds p. 821 - 823 (1991)
Update date:2022-07-30
Topics:
Kuroyan, R. A.
Pogosyan, S. A.
Grigoryan, N. P.
It was established by NMR and mass spectrometry that 1-oxaspiro<2,5>octane-2-carboxylic acid nitrile is converted, by the action of sodium malonate in toluene, to ethyl 2-oxo-4-cyano-1-oxaspiro<4,5>decane-3-carboxylate, which, upon refluxing in DMSO, is de-ethoxycarbonylated to give 2-oxo-1-oxaspiro<4,5>decane-4-carboxylic acid nitrile.The latter is converted to a thioamide, on the basis of which some thiazoles were synthesized.
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