USE OF t-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE FOR TETRAMIC ACID SYNTHESIS: TOTAL SYNTHESIS OF THE PLASMODIAL PIGMENT FULIGORUBIN A

Article abstract of DOI:10.1016/S0040-4039(00)82204-2

A short, efficient synthesis of the yellow slime mould pigment fuligorubin A (I) has been achieved using coupling of t-butyl 4-diethylphosphono-3-oxobutanethioate with deca-2,4,6,8-tetraenal and subsequent substitution with a glutamic acid derivative followed by Dieckmann cyclisation.