Diastereoselective α-iodination reaction of 4-alkenylamide having a β-chiral center

Article abstract of DOI:10.1016/S0040-4020(97)00382-7

α-Iodination reaction of 4-alkenylamide with a β-chiral center proceeds with high diastereoseletivity to give syn α-iodoalkenamide through the formation of cyclic ketene N,O-acetal and subsequent α-iodination from the opposite side of a β-substituent.