Synthesis of (3R)- and (3S)-3,4-diamino-butyric acid from L-aspartic acid

Article abstract of DOI:10.1080/00397919208020852

A short and convenient synthesis for both enantiomers of GABOB amino-analogue 1a,b is reported, starting from L-aspartic acid. The protected diester 3 is the common intermediate for the synthetic pathway.

Full text of DOI:10.1080/00397919208020852

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Synthetic Communications: An
International Journal for Rapid
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Organic Chemistry
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Synthesis of (3R)- and (3S)-3,4-
Diamino-Butyric Acid from L-
Aspartic Acid
D. Misiti a , M. Santaniello b & G. Zappia a
a Dip. Studi di Chimica e Tecnologia delle Sostanze
Biologicamente Attive , Universita “La Sapienza” ,
P.le A. Moro 5, 00185, Roma, Italy
b Lab. Ricerca Chimica , Sigma Tau S.p.A. , Via
Pontina km 30.400, 00040, Pomezia, Italy
Published online: 23 Sep 2006.
To cite this article: D. Misiti , M. Santaniello & G. Zappia (1992) Synthesis of (3R)-
and (3S)-3,4-Diamino-Butyric Acid from L-Aspartic Acid, Synthetic Communications:
An International Journal for Rapid Communication of Synthetic Organic Chemistry,
22:6, 883-891, DOI: 10.1080/00397919208020852
To link to this article: http://dx.doi.org/10.1080/00397919208020852
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