Enantioselective γ-Alkylation of α,β-Unsaturated Aldehydes Using New Cinchona-Based Primary Amine Catalyst

Article abstract of DOI:10.1002/ejoc.201901219

New cinchona-based primary amine catalysts were prepared and screened as organocatalysts for the γ-alkylation of α,β-unsaturated aldehydes with bis(4-dimethylaminophenyl)methanol. Catalyst C3 containing acetic acid group yielded γ-alkylated products in good yields (up to 94 %) with up to 90 % ee. This new primary aminocatalyst provide new opportunities to explore novel asymmetric transformations.