Synthesis and Biological Evaluation of Nα-(5-Deaza-5,6,7,8-tetrahydropteroyl)-L-ornithine

DOI: 10.1021/jm00089a009

Source and publish data:

Journal of Medicinal Chemistry p. 2002 - 2006 (1992)

Update date:2022-08-03

Topics:

Authors:

Singh, Shyam K.

Singer, Sara C.

Ferone, Robert

Waters, Kathleen A.

Mullin, Robert J.

Hynes, John B.

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Article abstract of DOI:10.1021/jm00089a009

A novel folic acid analogue, N^α-(5-deaza-5,6,7,8-tetrahydropteroyl)-L-ornithine, 3, was prepared via a multistep synthetic sequence.The key steps involved the conversion of 5-deazapteroic acid to its N¹⁰-formyl derivative followed by

Full text of DOI:10.1021/jm00089a009

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