Total synthesis of AMF-26, an antitumor agent for inhibition of the golgi system, targeting adp-ribosylation factor 1

DOI: 10.1021/jm301695c

Source and publish data:

Journal of Medicinal Chemistry p. 150 - 159 (2013)

Update date:2022-08-05

Topics:

Authors:

Shiina, Isamu

Umezaki, Yuma

Ohashi, Yoshimi

Yamazaki, Yuta

Dan, Shingo

Yamori, Takao

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Article abstract of DOI:10.1021/jm301695c

An effective method for the total synthesis of 1 (AMF-26), a potentially promising new anticancer drug that disrupts the Golgi system by inhibiting the ADP-ribosylation factor 1 (Arf1) activation, has been developed for the first time. The construction of

Full text of DOI:10.1021/jm301695c

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