Tetrahedron p. 2739 - 2760 (1992)
Update date:2022-08-04
Topics:
De Kimpe
De Cock
Stevens
The synthesis of N-(1-halo-2-alkylidene)amines, i.e. α-halomethyl ketimines, is described for the first time, utilizing the TiCl4-induced condensation of α-halomethyl ketones with primary amines. The reactivity of these new α-halomethylketimines was studied with respect to nucleophiles such as iodide, cyanide, alcohols, alkoxides, amines and thiolates. α-Halomethyl ketimines are powerful ambident electrophiles which underwent a variety of reactions leading to functionalized imines and heterocycles.
View MoreChongqing Yawei Fine Chemical Co.,Ltd
Contact:0086-23-62849407
Address:Ziyou village, Nanquan town, Banan district, Chongqing China
Changyi Xinxing Technology Development Co., Ltd.
Contact:0086-510-86651065(Time Zone:8),86651656
Address:94 Yingbinxilu WestRoad, Huangtu Town, Jiangyin City, Jiangsu, China
Contact:+86-371-67759225
Address:No.32, Jinsuo Road, High-tech Zone
Contact:86 311 85902108 / 85902109
Address:room 1001-1005 ,huanghe Road ,shijiazhuang ,China
Hunan Shineway Enterprise Co., Ltd.
Contact:+86-731-86303875
Address:118, Huanghua International Airport Road, Huanghua Town, Changsha, Hunan 410137, China
Doi:10.1016/S0040-4039(00)85100-X
(1986)Doi:10.1021/ja01308a049
(1935)Doi:10.1016/j.molcatb.2013.06.016
(2013)Doi:10.1021/om00043a076
(1992)Doi:10.1039/c2dt32487c
(2013)Doi:10.1021/acs.orglett.0c02378
(2020)
