A versatile synthesis of amino trifluoromethyl ketones and alcohols

DOI: 10.1016/S0040-4039(00)74166-9

Source and publish data:

Tetrahedron Letters p. 1879 - 1882 (1992)

Update date:2022-08-02

Topics:

Authors:

Begue, Jean-Pierre

Bonnet-Delpon, Daniele

Sdassi, Hamid

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Article abstract of DOI:10.1016/S0040-4039(00)74166-9

A short, selective and general route to α-amino trifluoromethyl ketones and corresponding alcohols is described via an easy epoxidation of 1-CF₃ enol ethers followed by an opening with various secondary amines.

Full text of DOI:10.1016/S0040-4039(00)74166-9

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Product name:1,1,1-Trifluoro-5-phenyl-3-piperazin-1-yl-pentan-2-one

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