Angewandte Chemie - International Edition p. 11611 - 11615 (2014)
Update date:2022-08-03
Topics:
Chen, Xiang-Yu
Gao, Zhong-Hua
Song, Chun-Yu
Zhang, Chun-Lin
Wang, Zhi-Xiang
Ye, Song
The catalytic cyclocondensation of in situ activated α,β-unsaturated carboxylic acids was developed. N-heterocyclic carbenes efficiently catalyzed the generation of α,β-unsaturated acyl azolium intermediates from α,β-unsaturated carboxylic acids via in situ generated mixed anhydrides for the enantioselective [3+2] and [3+3] cyclocondensation with α-amino ketones and alkyl(aryl)imines, respectively. The corresponding pyrrolidinones and dihydropyridinones were isolated in good yields with high to excellent enantioselectivities. Into the mix: N-Heterocyclic carbenes (NHCs) catalyze the generation of α,β-unsaturated acyl azoliums from α,β-unsaturated carboxylic acids via in situ generated mixed anhydrides for the enantioselective [3+2] and [3+3] cyclocondensation with sulfonylated α-amino ketones and alkyl(aryl)imines, respectively. The corresponding pyrrolidinones and dihydropyridinones were isolated in good yields with high to excellent enantioselectivities.
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Doi:10.1016/j.bmc.2012.11.009
(2013)Doi:10.1002/ardp.19662990903
(1966)Doi:10.1039/c2dt31999c
(2013)Doi:10.1021/ol3035142
(2013)Doi:10.1016/j.tetlet.2012.11.106
(2013)Doi:10.1021/om301176e
(2013)