Organic and Biomolecular Chemistry p. 35 - 38 (2019)
Update date:2022-08-03
Topics:
Baglai, Iaroslav
Leeman, Michel
Kellogg, Richard M.
Noorduin, Willem L.
A simple route to enantiomerically pure (S)-2-aminobutyramide-the chiral component of the anti-epileptic drugs Levetiracetam and Brivaracetam has been developed. This approach is based on the rational design and application of a Viedma ripening process. The practical potential of the process is demonstrated on a large scale.
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