Development of High-affinity 5-HT3 Receptor Antagonists. 2. Two Novel Tricyclic Benzamides

DOI: 10.1021/jm00083a015

Source and publish data:

Journal of Medicinal Chemistry p. 903 - 911 (1992)

Update date:2022-08-02

Topics:

Authors:

Youssefyeh, R. D.

Campbell, H. F.

Airey, J. E.

Klein, S.

Schnapper, M.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00083a015

Two new classes of potent 5-HT₃ agents have been developed and examined as inhibitors of cytotoxic drug induced emesis in the ferret and dog.The absolute configuration of the most active molecules 10 and 18 have been determined by X-ray crystal

Full text of DOI:10.1021/jm00083a015

Products guided by the article

Product name:N-(1-azabicyclo(2.2.2)octan-3-yl)-8-chloro-2,6-methano-3,4,5,6-tetrahydro-2H-1-benzoxocin-10-carboxamide

Cas No:141979-80-8

R&D Labs maybe for 141979-80-8

Kunshan Yalong Trading Co,.Ltd

Contact:86-512-57621185

Address:805-807 Room Hongqiao Mansion ,1088 West Qianjin Road, Kunshan, Jiangsu，China
Shanghai Yuanye Bio-Technology Co., Ltd.

website:http://www.shyuanye.com

Contact:+86-21-61845781

Address:Building 6, No. 465, Changta Road,Songjiang District,Shanghai,China
Antimex Chemical Limied

website:http://www.antimex.com

Contact:0086-21-50563169

Address:Room1027,No.Jinyu Road,Pudong
Nanjing Vincero International Trading Co.,Ltd

Contact:8618936897229

Address:NO.68, ZhuShan Road, JiangNing WanDa Plaza, Building E Room 1703
Changzhou Sunsheng Chem Co., Ltd

Contact:+1-(989)-854-0648

Address:No. 28 Yinshan Rd., Xixiashu Industrial Park

Relevant to this article

Crystal structures of four inclusion compounds of 2,2′-dithiosalicylic acid and tetraalkylammonium

Doi:10.1080/15421406.2017.1415661
(2017)
REACTION OF 2,3-DIHYDRO-4-PHENYL-1H-1,5-BENZODIAZEPINETHIONE-2 WITH ACETYLHYDRAZINE

Doi:10.1007/BF00486819
(1991)
The tert-butyl sulfoxide directed ortho metalation group. New synthetic methodology for substituted aromatics and pyridines and comparison with other metalation directors

Doi:10.1016/S0040-4039(00)79042-3
(1992)
Iridium-catalyzed asymmetric hydroalkynylation reactions of oxabenzonorbornadienes

Doi:10.1039/c2ob26775f
(2013)
A study on the diastereoselective synthesis of α-fluorinated β³-amino acids by α-fluorination

Doi:10.1002/hlca.201200520
(2012)
An efficient CuI/DBU-catalyzed one-pot protocol for synthesis of 1,4-disubstituted 1,2,3-triazoles

Doi:10.1039/c6ra23789d
(2016)

Article Doi