Development of High-affinity 5-HT3 Receptor Antagonists. 2. Two Novel Tricyclic Benzamides

Article abstract of DOI:10.1021/jm00083a015

Two new classes of potent 5-HT₃ agents have been developed and examined as inhibitors of cytotoxic drug induced emesis in the ferret and dog.The absolute configuration of the most active molecules 10 and 18 have been determined by X-ray crystal