TSAO analogues. Stereospecific synthesis and anti-HIV-1 activity of 1- [2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3'-spiro-5''-(4''- amino-1'',2''-oxathiole 2'',2''-dioxide) pyrimidine and pyrimidine-modified nucleosides

DOI: 10.1021/jm00094a009

Source and publish data:

Journal of Medicinal Chemistry p. 2988 - 2995 (1992)

Update date:2022-08-05

Topics:

Authors:

Perez-Perez

San-Felix

Balzarini

De Clercq

Camarasa

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Article abstract of DOI:10.1021/jm00094a009

Several analogues of a new lead for anti-HIV-1 agents [1-[2',5'-bis-O- (tert-butyldimethylsilyl)-β-D-ribofuranosyl]-thymine]-3'-spiro-5''-(4''- amino-1'',2''-oxathiole 2'',2''-dioxide) (TSAO) modified at positions N-3, O- 4 and C-5 of the thymine moiety,

Full text of DOI:10.1021/jm00094a009

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Product name:1-[(6R,8R,9R)-4-amino-9-{[tert-butyl(dimethyl)silyl]oxy}-6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]-5-methyl-3-(3-methylbut-2-en-1-yl)pyrimidine-2,4(1H,3H)-dione

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