Inhibition of N8-acetylspermidine deacetylase by active-site-directed metal coordinating inhibitors.

DOI: 10.1021/jm00091a009

Source and publish data:

Journal of medicinal chemistry p. 2414 - 2418 (1992)

Update date:2022-08-04

Topics:

Authors:

Huang Huang

Dredar Dredar

Manneh Manneh

Blankenship

Fries Fries

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Article abstract of DOI:10.1021/jm00091a009

A number of substrate analogues of N8-acetylspermidine (N8-AcSpd) (16) and chemical modifying agents containing metal coordinating ligands were assayed as inhibitors of the cytoplasmic enzyme N8-AcSpd deacetylase from rat liver. The enzyme is inhibited by

Full text of DOI:10.1021/jm00091a009

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