A catalytic enantioselective reaction using a C2-symmetric disulfonamide as a chiral ligand: Cyclopropanation of allylic alcohols by the Et2Zn-CH2I2-disulfonamide system

Article abstract of DOI:10.1016/S0040-4039(00)92246-9

The first catalytic, enantioselective Simmons-Smith cyclopropanation of an allylic alcohol has been achieved by the reaction of an allylic alcohol with Et₂Zn and CH₂I₂ in the presence of a catalytic amount of chiral disulfonamide 1.