Gram-scale quaternarization of the anomeric position of carbohydrates: Dramatic effects of molecular sieves on rhodium(II)-mediated decomposition of diazo sugars

Article abstract of DOI:10.1055/s-0032-1317013

The optimization of rhodium(II) carbene mediated quaternarization of the anomeric position of carbohydrates is reported. Preparation of ketopyranosides in good and reliable yields requires reverse addition of the substrate to a highly diluted suspension o