Synthesis of α,α-Disubstituted α-Amino Acid Amides by Phase-Transfer Catalyzed Alkylation

DOI: 10.1016/S0040-4039(00)61112-7

Source and publish data:

Tetrahedron Letters p. 6007 - 6010 (1992)

Update date:2022-08-02

Topics:

Authors:

Kaptein, Bernard

Boesten, Wilhelmus H. J.

Broxterman, Quirinus B.

Schoemaker, Hans E.

Kamphuis, Johan

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Article abstract of DOI:10.1016/S0040-4039(00)61112-7

α,α-Disubstituted α-amino acid amides were prepared in 17-88 percent chemical yield by the phase-transfer catalyzed alkylation of N-benzylidene α-H amino acid amides, followed by weak acidic hydrolysis of the Schiff bases.

Full text of DOI:10.1016/S0040-4039(00)61112-7

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