New total synthesis of bikaverin

Article abstract of DOI:10.1016/S0040-4039(00)78863-0

On the basis of non-catalysed thermal condensation of a Mannich based with a phenol, followed by dehydration to an o.quinonic chromene further isomerized to a p.quinonic one, the synthesis of bikaverin 7 has been achieved via a six-step route involving selective dealkylation of bikaverin-dimethylether 6.