Synthesis and antifungal activity of some new miscellaneous S-triazoles

Article abstract of DOI:10.1080/10426500108045271

The reaction of aryloxyacelic acid with thiocarbohydrazide under condition of fusion gave the corresponding s-triazole derivatives 2a-c. The dicyano derivatives 3, 4 were obtained via reaction of compound 2c with [bis(methylsulfanyl)methylidine]malononitrile and/or ethoxymethylenemalononitrile. Interaction of compound 2c with bromomalononitrile yielded the corresponding triazolothiadiazine derivative 5. In addition reaction of compound 2c with phenyl isothiocyanate furnished triazolothiadiazole derivative 6. Fusion of arylaminoacetic acids 8, 9 with thiocarbohydrazide afforded s-triazole derivatives 10, 11, respectively. The reaction of benzylthioacetic acid 12 with thiocarbohydrazide yielded the triazole derivative 13. When cyanoacetic acid 14 was reacted with thiocarbohydrazide the pyrazolotriazole derivative 16 was obtained. Some of the obtained compounds showed remarkable antifungal activity comparable to the fungicide Mycostatine.

Full text of DOI:10.1080/10426500108045271

This article was downloaded by: [University of Guelph]
On: 13 May 2012, At: 15:52
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954
Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH,
UK
Phosphorus, Sulfur, and Silicon
and the Related Elements
Publication details, including instructions for
authors and subscription information:
http://www.tandfonline.com/loi/gpss20
SYNTHESIS AND ANTIFUNGAL
ACTIVITY OF SOME NEW
MISCELLANEOUS S-TRIAZOLES
M. M. Ghorab a , A. M. Sh. El-Sharief b , Y. A. Ammar
b & Sh. I. Mohamed b
a Department of Drug Radiation Research, National
Center or Radiation Research and Technology, P.O.
Box 29, Nasr City, Cairo, Egypt
b Department of Chemistry, Faculty of Science, Al-
Azhar University, Nasr City, P.O. Box 11884, Cairo,
Egypt
Available online: 04 Oct 2006
To cite this article: M. M. Ghorab, A. M. Sh. El-Sharief, Y. A. Ammar & Sh. I. Mohamed
(2001): SYNTHESIS AND ANTIFUNGAL ACTIVITY OF SOME NEW MISCELLANEOUS S-
TRIAZOLES, Phosphorus, Sulfur, and Silicon and the Related Elements, 173:1, 223-233
To link to this article: http://dx.doi.org/10.1080/10426500108045271
PLEASE SCROLL DOWN FOR ARTICLE
Full terms and conditions of use: http://www.tandfonline.com/page/terms-
and-conditions
This article may be used for research, teaching, and private study purposes.
Any substantial or systematic reproduction, redistribution, reselling, loan,
sub-licensing, systematic supply, or distribution in any form to anyone is
expressly forbidden.

The publisher does not give any warranty express or implied or make any
representation that the contents will be complete or accurate or up to
date. The accuracy of any instructions, formulae, and drug doses should be
independently verified with primary sources. The publisher shall not be liable
for any loss, actions, claims, proceedings, demand, or costs or damages
whatsoever or howsoever caused arising directly or indirectly in connection
with or arising out of the use of this material.