New vitamin D3 derivatives with unexpected antiproliferative activity: 1-(hydroxymethyl)-25-hydroxyvitamin D3 homologs.

DOI: 10.1021/jm00095a026

Source and publish data:

Journal of medicinal chemistry p. 3280 - 3287 (1992)

Update date:2022-07-29

Topics: Derivatives Vitamin D3 Antiproliferative

Authors:

Posner Posner

Nelson Nelson

Guyton Guyton

Kensler Kensler

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Article abstract of DOI:10.1021/jm00095a026

Surprisingly, both of the synthetic 1-(hydroxymethyl)-25-hydroxyvitamin D3 diastereomers (-)-2 and (+)-3 retained the antiproliferative activity of natural calcitriol in murine keratinocytes. Preliminary studies indicated, however, that both of these synt

Full text of DOI:10.1021/jm00095a026

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