Asymmetric transfer hydrogenation of 1-naphthyl ketones by an ansa-Ru(II) complex of a DPEN-SO2N(Me)-(CH2)2(η 6-p-tol) combined ligand

DOI: 10.1021/ol400393j

Source and publish data:

Organic Letters p. 1614 - 1617 (2013)

Update date:2022-07-30

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Authors:

Kisic, Andrea

Stephan, Michel

Mohar, Barbara

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Article abstract of DOI:10.1021/ol400393j

The first second-generation designer Ru(II) catalyst 1b featuring an enantiopure N,C-(N-ethylene-N-methyl-sulfamoyl)-tethered (DPEN- κ²N,N′)/η⁶-toluene hybrid ligand is introduced. Using an S/C = 1000 in HCO₂H-Et₃N 5:2 transfer hydrogenation medium, secondary 1-naphthyl alcohols are obtained in up to >99.9% ee under mild conditions. Mechanistic factors are discussed.

Full text of DOI:10.1021/ol400393j

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