Tetrahedron Letters p. 7743 - 7746 (1995)
Update date:2022-07-30
Topics:
Andrews
Bannister
Etridge
Lewis
Mullane
Wells
The reversible (H+/K+)ATPase inhibitor SKandF 96067 1 was prepared in two steps from Meldrun's Acid by cyclisation of the acrylamide 4 with Ph3P/C2Cl6/Et3N. Evidence for the formation of imidoylketene imine 3 was obtained by trapping with phenyl isocyanate. Thermal degradation of an amidine such as 12 also gave SKandF 96067 1.
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Doi:10.1080/00397919208021322
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