Syntheses of cerulenin and its analogs. I. Cerulenin and its analogs with modified side chain

DOI: 10.1248/cpb.40.2945

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2945 - 2953 (1992)

Update date:2022-07-29

Topics:

Authors:

Morisaki

Funabashi

Furukawa

Shimazawa

Kanematsu

Ando Ando

Okuda Okuda

Iwasaki Iwasaki

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Article abstract of DOI:10.1248/cpb.40.2945

Optically active cerulenin 1, a potent inhibitor of fatty acid synthetase, was prepared via the condensation of the epoxy aldehyde 8 and the alkenyl lithium 16. In order to evaluate the effects of (E,E)-1,4-double bonds of the cerulenin side chain on the interaction with the enzyme, a series of optically active cerulenin analogs 32a-i with modified side chains and tetrahydrocerulenin 3 were synthesized by similar procedures.

Full text of DOI:10.1248/cpb.40.2945

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