Chemical and Pharmaceutical Bulletin p. 2945 - 2953 (1992)
Update date:2022-07-29
Topics:
Morisaki
Funabashi
Furukawa
Shimazawa
Kanematsu
Ando
Okuda
Iwasaki
Optically active cerulenin 1, a potent inhibitor of fatty acid synthetase, was prepared via the condensation of the epoxy aldehyde 8 and the alkenyl lithium 16. In order to evaluate the effects of (E,E)-1,4-double bonds of the cerulenin side chain on the interaction with the enzyme, a series of optically active cerulenin analogs 32a-i with modified side chains and tetrahydrocerulenin 3 were synthesized by similar procedures.
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