Reductive Cyclization of Carbon-Centered Glycine Radicals; A Novel Synthetic Route to Cyclic α-Amino Acids

Article abstract of DOI:10.1016/S0040-4020(01)81240-0

Reductive cyclizations (tributyltin hydride, AIBN) of several α-(phenylthio)glycine derivatives with a 3-alkenyl substituent at nitrogen are reported.These reactions proceed via 2-aza-5-alken-1-yl radicals as intermediates which bear electron-withdrawing