ACCEPTED MANUSCRIPT
References
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(2) September 2012 substructure search in ChEMBL database revealed 33942 bioactive
compounds bearing the fragment of morpholine.
(3) Nineteen small molecule FDA-approved drugs contain morphloline unit: Wishart, D. S.;
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(11) Selected Books: (a) Modern Fluoroorganic Chemistry, Kirsch, P., Ed.; Wiley-VCH,
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(12) At the moment, at least 45 FDA-approved drugs bear the trifluoromethyl group (Ref. 3).
(13) Soloshonok, V.A., editor. Fluorine-Containing Synthons. American Chemical Society;
Washington, DC: 2005.
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