Asymmetric Synthesis of β-Lactams. Highly Diastereoselective Alkylation of Chiral 2-Cyano Esters

DOI: 10.1021/jo00088a034

Source and publish data:

Journal of Organic Chemistry p. 2497 - 2505 (1994)

Update date:2022-07-30

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Authors:

Cativiela, Carlos

Diaz-de-Villegas, Maria D.

Galvez, Jose A.

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Article abstract of DOI:10.1021/jo00088a034

Enolates derived from 10-(dicyclohexylsulfamoyl)isobornyl 2-substituted-2-cyanoacetates were alkylated with very good yield and high diastereoselectivity.The reduction of the resulting reaction products and subsequent cyclization of the β-amino acids led

Full text of DOI:10.1021/jo00088a034

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