SYNTHESIS of 1,2,4-TRIAZINES - XIV. Regioselective Synthesis of Ethyl 1,2,4-Triazine-5-carboxylates

Article abstract of DOI:10.1016/S0040-4020(01)89020-7

Ethyl 1,2,4-triazine-5-carboxylates 6 were prepared by heating N,N-dimethylaminomethylene- or ethoxymethylenehydrazones 5 with ammonium acetate in acetic acid at 100 deg C.NMR studies confirmed the absence of their regio isomers (6-carboxylates), showing