Synthetic Investigations of Rapamycin. 1. Synthesis of a C10-C21 Fragment

DOI: 10.1021/jo00045a007

Source and publish data:

Journal of Organic Chemistry p. 5058 - 5060 (1992)

Update date:2022-09-26

Topics:

Authors:

Meyer, Stephanie D.

Miwa, Tetsuo

Nakatsuka, Masashi

Schreiber, Stuart L.

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Article abstract of DOI:10.1021/jo00045a007

Phosphine oxide 2, representing the C10-C21 portion of rapamycin, was stereoselectively synthesized and was demonstrated to undergo a Horner-Wittig reaction to form triene 25 as an 8:1 mixture of trans-cis isomers.

Full text of DOI:10.1021/jo00045a007

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