Flavones. 3. Synthesis, biological activities, and conformational analysis of isoflavone derivatives and related compounds

DOI: 10.1021/jm00097a009

Source and publish data:

Journal of Medicinal Chemistry p. 3519 - 3525 (1992)

Update date:2022-07-30

Topics: Synthesis Regioselectivity Derivatives Biological activities Pharmacophore Cyclization HPLC (high-performance liquid chromatography) X-ray crystallography Docking Studies Substituent Effects Structure-Activity Relationship (SAR) Conformational Analysis Flavones Isoflavone Spectroscopic Characterization Antioxidant assay SAR (Structure-Activity Relationship) MTT assay

Authors:

Loch III

Toder Toder

Borrelli

Gawlak Gawlak

Radov Radov

Gensmantel

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Article abstract of DOI:10.1021/jm00097a009

A series of 2-alkylisoflavone derivatives 1 was prepared with the intent to study the importance of the phenyl group (at the 3-position) of the isoflavone in imparting antihypertensive activity and the substitution effects at the 2-position of isoflavone.

Full text of DOI:10.1021/jm00097a009

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