Journal of Medicinal Chemistry p. 3519 - 3525 (1992)
Update date:2022-07-30
Topics: Synthesis Regioselectivity Derivatives Biological activities Pharmacophore Cyclization HPLC (high-performance liquid chromatography) X-ray crystallography Docking Studies Substituent Effects Structure-Activity Relationship (SAR) Conformational Analysis Flavones Isoflavone Spectroscopic Characterization Antioxidant assay SAR (Structure-Activity Relationship) MTT assay
Wu
Loch III
Toder
Borrelli
Gawlak
Radov
Gensmantel
A series of 2-alkylisoflavone derivatives 1 was prepared with the intent to study the importance of the phenyl group (at the 3-position) of the isoflavone in imparting antihypertensive activity and the substitution effects at the 2-position of isoflavone.
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Doi:10.1002/asia.201500865
(2016)Doi:10.1039/c4cc00967c
(2014)Doi:10.1016/S0040-4039(00)74671-5
(1992)Doi:10.1016/S0223-5234(97)86175-2
(1996)Doi:10.1016/0040-4039(92)88102-B
(1992)Doi:10.1016/S0008-6215(00)90493-2
(1992)
