A VERSATILE AND STEREOSPECIFIC SYNTHESIS OF A DIHYDROXYETHYLENE DIPEPTIDE ISOSTERE OF RENIN INHIBITORS FROM D-RIBOSE

DOI: 10.1016/S0040-4039(00)92504-8

Source and publish data:

Tetrahedron Letters p. 3567 - 3570 (1992)

Update date:2022-08-04

Topics:

Authors:

Chan, Ming Fai

Hsiao, Chi-Nung

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Article abstract of DOI:10.1016/S0040-4039(00)92504-8

(2S,3R,4S)-2-Amino-1-cyclohexyl-6-methylheptane-3,4-diol, a dihydroxyethylene dipeptide isostere for renin inhibitors, was synthesized from D-ribose stereospecifically.This method can be readily adapted to other dihydroxyethylene isosteres.

Full text of DOI:10.1016/S0040-4039(00)92504-8

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