Simplified synthesis of 2′ -O-alkyl ribopyrimidines

Article abstract of DOI:10.1016/0040-4039(95)00435-F

Direct 2′-hydroxyl alkylation (R = methyl, ethyl, propyl, pentyl or allyl) of 5′-dimethoxytrityl-N-(t-butylphenoxyacetyl or benzoyl)-cytidine 1 was achieved by reaction in the presence of silver I oxide and a catalytic amount of pyridine with excess alkyl