Synthesis and evaluation of 2-pyridinone derivatives as HIV-1 specific reverse transcriptase inhibitors. 1. Phthalimidoalkyl and -alkylamino analogues

DOI: 10.1021/jm00099a006

Source and publish data:

Journal of Medicinal Chemistry p. 3784 - 3791 (1992)

Update date:2022-07-30

Topics:

Authors:

Hoffman Hoffman

Wai Wai

Thomas Thomas

Levin Levin

O'Brien O'Brien

Goldman Goldman

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Article abstract of DOI:10.1021/jm00099a006

A potent (IC₅₀ = 30 nM), specific nonnucleoside HIV-1 reverse transcriptase (RT) inhibitor 3-[N-(phthalimidomethyl)amino]-5-ethyl-6- methylpyridin-2(1H)-one (1), was discovered through an in vitro screening program. This compound did not inhibi

Full text of DOI:10.1021/jm00099a006

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