Synthesis and evaluation of 2-pyridinone derivatives as HIV-1 specific reverse transcriptase inhibitors. 1. Phthalimidoalkyl and -alkylamino analogues

Article abstract of DOI:10.1021/jm00099a006

A potent (IC₅₀ = 30 nM), specific nonnucleoside HIV-1 reverse transcriptase (RT) inhibitor 3-[N-(phthalimidomethyl)amino]-5-ethyl-6- methylpyridin-2(1H)-one (1), was discovered through an in vitro screening program. This compound did not inhibi