Synthesis of C-2 substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines: Binding studies on opioid receptors

Article abstract of DOI:10.1016/0223-5234(92)90150-Y

The racemic C-2 substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines 8a-k were prepared in three steps from the readily available 2-cyano-1,2,5,6-tetrahydropyridines 4a-c. This involved alkylation of the anion of 4a-c with the appropriate alkyl ha