Practical synthesis of T-3761, (S)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyr ido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid

DOI: 10.1248/cpb.42.2629

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2629 - 2632 (1994)

Update date:2022-08-04

Topics:

Authors:

Todo Todo

Takagi Takagi

Iino Iino

Hayashi Hayashi

Takata Takata

Kuroda Kuroda

Momonoi Momonoi

Narita Narita

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Article abstract of DOI:10.1248/cpb.42.2629

An economical 11-step synthesis of T-3761 (1), a new quinolone antibacterial agent discovered by us, has been developed. Commercially available 2,3,4,5-tetrafluorobenzoic acid (2) has been transformed to 4-(1-acetaminocyclopropyl)-2,3,5-trifluorobenzoic a

Full text of DOI:10.1248/cpb.42.2629

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