Synthesis of N-Boc-Protected 1-Amino-3-alken-2-ols from Allylic Carbamates via Palladium(II)-Catalyzed Oxidative Cyclization

Article abstract of DOI:10.1021/jo00049a001

Methyl glyoxylate adducts of N-Boc-protected allylic amines cyclize in the presence of catalytic Pd(OAc)2 and excess Cu(OAc)2 in DMSO to 5-(1-alkenyl)-2-(methyoxycarbonyl)oxazolidines.These heterocycles are readily converted to unsaturated.N-Boc-protected