Calixarenes as buliding blocks for molecular receptors

Article abstract of DOI:10.1002/recl.19921110704

Molecular receptors for organic molecules are described in which calix<4>arene is used as a molecular platform rather than for its cavity.This is illustrated by the synthesis of a receptor for barbiturates, a calix<4>arene in a cone conformation containing two diaminotriazine moieties at the upper rim.This receptor (9) forms a molecular cleft in which phenobarbital complexes by hydrogen bonding both triazine rings.The association constant K is 520M^-1, when the self-association of the barbiturate is taken into account.