Short-step synthesis of chiral C2-symmetric 2,3,4,5-tetrasubstituted pyrrolidines from D-mannitol and their use as chiral ligands in the reaction of diethylzinc and benzaldehyde

Article abstract of DOI:10.1016/S0040-4039(00)61197-8

(3R,4R)-bis(hydroxy)-(2S,5S)-bis(hydroxymethyl)-pyrrolidine and related chiral C₂-symmetric pyrrolidines including D₂-symmetric 1,2-bis(1-pyrrolidino)-ethanes and N-hydroxyethylpyrrolidines were synthesized highly practically from D-