DIASTEREOSELECTIVE DOUBLE MICHAEL ADDITIONS OF VINYLOGOUS ESTERS AND THEXYLDIMETHYLSILYL TRIFLATE-INDUCED CYCLIZATIONS

DOI: 10.1016/S0040-4039(00)92283-4

Source and publish data:

Tetrahedron Letters p. 4691 - 4694 (1991)

Update date:2022-08-05

Topics:

Authors:

Schinzer, Dieter

Kalesse, Markus

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)92283-4

Double Michael additions of vinylogous esters of type 1 with crotyl ester generates diastereoselectively bicyclo<2.2.2>octanone 2 with four defined chiral centers via a synclinal transition state.Thexyldimethylsilyl enol ethers of type 5 and 10 undergo smooth cyclization to bicyclo<3.3.1>nonenones 7 and bicyclo<3.3.0>octenones 12 by addition of Lewis acids.

Full text of DOI:10.1016/S0040-4039(00)92283-4

Products guided by the article

Product name:3-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-4-methoxy-1-methyl-cyclohexa-2,4-dienyl}-propionic acid methyl ester

Cas No:144355-09-9

R&D Labs maybe for 144355-09-9

Nanyang Tianhua pharmaceutical Co.,Ltd.

Contact:+8618639816203

Address:Longsheng Industrial Park
Shanghai Sunwise Chemical Co., Ltd

website:http://www.sunwisechem.com

Contact:86-021-33883180

Address:Room 10E, Building G, Westlink Center, No. 2337 Gudai Road, Minhang District, Shanghai, China PC: 201100
Hubei Sibo Technology Co.,Ltd.

Contact:0715-6597222

Address:Pan Jia Wan fan Lake Chemical Industrial Park ,Xianning City, Hubei, China
SHIFANG SUHONG CHEMICAL CO.,LTD

Contact:+86-838-2224563

Address:Room 1207 Zongchen Sunshine No.128 Taishan South Road,Deyang City,Sichuan China
Acorn PharmaTech Co., Ltd

Contact:86-25-58619180

Address:Nanjing High-Tech Zone 10 Xinghuo Road Pukou District Nanjing, Jiangsu 210061 The People's Republic of China

Relevant to this article

Synthesis of 6-(arylmethylidene)octahydropyrrolo[1,2-a]pyrimidines and 5-(arylmethylidene)hexahydropyrrolo[1,2-a]imidazoles by the interaction of alk-4-ynals with a,?-diaminoalkanes in DMSO in the presence of KOH

Doi:10.1016/j.mencom.2013.05.006
(2013)
A convenient synthesis of 2-azetidinones via 2-fluoro-1-methylpyridinium p-toluenesulfonate

Doi:10.1007/s00706-012-0918-y
(2013)
Quantifying Through-Space Substituent Effects

Doi:10.1002/anie.202006943
(2020)
Structural Study and Reactivity of Carbanions in Solution: Phenyl- and 3-Pyridylacetonitriles

Doi:10.1021/jo00050a015
(1992)
Catalyst-Free, Metal-Free, and Chemoselective Transamidation of Activated Secondary Amides

Doi:10.1055/s-0037-1610664
(2019)
Syntheses of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid analogues modified by α-acylaminoamido groups at the C-4 position using isocyanide-based four-component coupling and biological evaluation as inhibitors of human parainfluenza virus type 1

Doi:10.1248/cpb.c12-00834
(2013)

Article Doi