The squalestatins: Synthesis and biological activity of some C3-modified analogues; replacement of a carboxylic acid or methyl ester with an isoelectronic heterocyclic functionality

DOI: 10.1021/jm00018a010

Source and publish data:

Journal of Medicinal Chemistry p. 3502 - 3513 (1995)

Update date:2022-08-02

Topics: Synthesis Esterification Methyl ester Carboxylic acid Biological Activity Inhibition Replacement squalestatins Isoelectronic

Authors:

Bamford Bamford

Chan Chan

Craven Craven

Dymock Dymock

Green Green

Henson Henson

Kirk Kirk

Lester Lester

Procopiou

Snowden Snowden

Spooner Spooner

Srikantha

Watson Watson

Widdowson

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00018a010

A series of squalestatins modified at the C3-position with a heterocyclic functionality was prepared and evaluated in vitro as inhibitors of squalene synthase (SQS). Structure-activity relationships for compounds with the 4,6- dimethyloctenoate at C6(S1 a

Full text of DOI:10.1021/jm00018a010

Products guided by the article

Product name:<1S-<1α(4R*,5S*),3α,4β,5α,6α(2E,4R*,6R*),7β>>-1-<4-(acetyloxy)-5-methyl-3-methylene-6-phenylhexyl>-4,6,7-trihydroxy-2,8-dioxabicyclo<3.2.1>octane-3,4,5-tricarboxylic acid, 6-(4,6-dimethyl-2-octenoate), 3,4,5-tris-(4-nitrobenzyl) ester

Cas No:144358-43-0

R&D Labs maybe for 144358-43-0

Suzhou Sinosun Imp.&Exp. Corporation

website:http://www.szsinosun.com

Contact:+86-512-63488895,63488616

Address:No.758 East Jiangling Road Wujiang Economic & Technological Developmenty Zone Jiangsu China
SuZhou Bichal Biological Technology CO.,LTD

Contact:+86-512-68051130

Address:NO.32 huoju road HI-TECH Industrial development zone SuZhou China
QUZHOU ZIO I/E CO.;LTD

Contact:13357117572

Address:No.149 Shiji dadao Road.
Chengdu Pukang Biotechnology Co., Ltd

website:http://www.pu-kang.com

Contact:86-028-63976226

Address:No. 868 Xiwang Road,Xinjin county,Chengdu city, China
Chengdu King-tiger Pharm-chem. Tech. Co., Ltd

Contact:028-85317716

Address:Tianfu Life Science Park, No. 88 South Keyuan Road, Gaoxin District, Chengdu City, Sichuan Province, PRC.

Relevant to this article

Synthesis and properties of pyrrolidine-based negatively charged dna mimics

Doi:10.1080/15257770701548345
(2007)
Doi:10.1038/201610a0
(1964)
Ratiometric fluorescent probes for detection of intracellular singlet oxygen

Doi:10.1021/ol401421r
(2013)
Enzyme-Activated Antagonists of the Strychnine-Insensitive Glycine/NMDA Receptor

Doi:10.1021/jm00029a003
(1994)
Co(iii)(salen)-catalyzed phenolic kinetic resolution of two stereocentered benzyloxy and azido epoxides: Its application in the synthesis of ICI-118,551, an anti-hypertensive agent

Doi:10.1039/c3ob42501k
(2014)
New and efficient synthesis of 1,3-dienylphosphonates by palladium-catalyzed substitution of propargylic esters to diethyl phosphite

Doi:10.1080/00397911.2012.725795
(2013)

Article Doi