The squalestatins: Synthesis and biological activity of some C3-modified analogues; replacement of a carboxylic acid or methyl ester with an isoelectronic heterocyclic functionality

DOI: 10.1021/jm00018a010

Source and publish data:

Journal of Medicinal Chemistry p. 3502 - 3513 (1995)

Update date:2022-08-02

Topics: Synthesis Esterification Methyl ester Carboxylic acid Biological Activity Inhibition Replacement squalestatins Isoelectronic

Authors:

Bamford Bamford

Chan Chan

Craven Craven

Dymock Dymock

Green Green

Henson Henson

Kirk Kirk

Lester Lester

Procopiou

Snowden Snowden

Spooner Spooner

Srikantha

Watson Watson

Widdowson

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Article abstract of DOI:10.1021/jm00018a010

A series of squalestatins modified at the C3-position with a heterocyclic functionality was prepared and evaluated in vitro as inhibitors of squalene synthase (SQS). Structure-activity relationships for compounds with the 4,6- dimethyloctenoate at C6(S1 a

Full text of DOI:10.1021/jm00018a010

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