Synthesis and Antiviral Activity of Deoxy Analogs of 1--6-(phenylthio)thymine (HEPT) as Potent and Selective Anti-HIV-1 Agents

DOI: 10.1021/jm00103a009

Source and publish data:

Journal of Medicinal Chemistry p. 4713 - 4719 (1992)

Update date:2022-09-26

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Authors:

Tanaka, Hiromichi

Takashima, Hideaki

Ubasawa, Masaru

Sekiya, Kouichi

Nitta, Issei

et al. et al.

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Article abstract of DOI:10.1021/jm00103a009

The effect of substitution in the acyclic structure of 1-<(2-hydroxyethoxy)methyl>-6-(phenylthio)thymine (HEPT) on anti-HIV-1 activity was investigated by synthesizing a series of deoxy analogs and related compounds.Preparation of 1-<(2-alkyloxyethoxy)met

Full text of DOI:10.1021/jm00103a009

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Product name:2,4(1H,3H)-Pyrimidinedione, 1,3,5-trimethyl-6-(phenylthio)-

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