Enzyme-Catalysed Hydrolysis of N-Benzyloxycarbonyl-cis-2,6-(acetoxymethyl)piperidine. A Facile Route to Optically Active Piperidines

DOI: 10.1016/S0957-4166(00)86034-6

Source and publish data:

Tetrahedron Asymmetry p. 1021 - 1024 (1992)

Update date:2022-07-30

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Authors:

Chenevert, Robert

Dickman, Michael

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Article abstract of DOI:10.1016/S0957-4166(00)86034-6

We report the first enzymatic asymmetrization of a piperidine system.Hydrolysis of N-benzyloxycarbonyl-cis-2,6-(acetoxymethyl)piperidine in the presence of Aspergillus niger lipase gave the corresponding 2R, 6S mono-acetate in good chemical yield and very

Full text of DOI:10.1016/S0957-4166(00)86034-6

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