Tetrahedron Letters p. 5105 - 5106 (1992)
Update date:2022-08-02
Topics:
Gomez, Ana M.
Valverde, Serafin
Lopez, J. Cristobal
A stereospecific route to highly functionalized 2,5-disubstituted tetrahydrofuran derivatives from readily available 6-O-silylated-hex-2-enono-δ-lactones is reported.The protocol involves an efficient Michael type O-heterocyclization reaction followed by selective ring opening of the lactone moiety.
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