Stereocontrolled Entry to 2,5-Disubstituted Tetrahydrofurans from Hex-2-enono-δ-lactones under Mild Conditions

DOI: 10.1016/S0040-4039(00)61202-9

Source and publish data:

Tetrahedron Letters p. 5105 - 5106 (1992)

Update date:2022-08-02

Topics:

Authors:

Gomez, Ana M.

Valverde, Serafin

Lopez, J. Cristobal

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Article abstract of DOI:10.1016/S0040-4039(00)61202-9

A stereospecific route to highly functionalized 2,5-disubstituted tetrahydrofuran derivatives from readily available 6-O-silylated-hex-2-enono-δ-lactones is reported.The protocol involves an efficient Michael type O-heterocyclization reaction followed by selective ring opening of the lactone moiety.

Full text of DOI:10.1016/S0040-4039(00)61202-9

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