CYTOCHALASINS U AND V, TWO NEW CYTOCHALASANS, FROM PHOMA EXIGUA VAR. HETEROMORPHA

Article abstract of DOI:10.1016/S0040-4020(01)88222-3

Two additional cytochalasins were isolated from liquid culture filtrates of Phoma exigua var. heteromorpha together with some already known cytochalasins.The two new metabolites, named cytochalasin U and V, represent the first natural occurrence of a 25,26-dioxa<16> and 25-oxa<15>cytochalasan, respectively, both bearing a formyl group on the macrocyclic ring.Cytochalasins U and V showed respectively significant and weak activity in the brine shrimp assay.