Storable palladacycles for selective functionalization of alkyne-containing proteins

Article abstract of DOI:10.1039/c3cc43479f

We report the facile preparation of palladacycles as storable arylpalladium(ii) reagents from acetanilides via cyclopalladation. The palladacycles exhibit good stability in PBS buffer and are capable of functionalizing a metabolically encoded HPG-containing protein, thus providing a new type of biocompatible organometallic reagent for selectively functionalizing the alkyne-encoded proteins.