Synthesis of ω-fluorinated octanoic acid and its β-substituted derivatives

Article abstract of DOI:10.1016/S0022-1139(00)81186-0

Simple syntheses are described for the ω-fluorinated analogs of octanoic acid and its β-substituted derivatives in which insertion of a methyl and dimethyl group, and oxygen substitution at the C-3 position are involved, employing nucleophilic displacement with fluoride ion of the tosylate functions in the later stage of synthesis.The synthetic procedures offer easy and convenient acces to the corresponding 18F-labeled analogs using the readily available <18F>fluoride ion.