Structure-based design, synthesis by click chemistry and in vivo activity of highly selective A3 adenosine receptor agonists

Article abstract of DOI:10.1039/c4md00571f

2-Arylethynyl derivatives of (N)-methanocarba adenosine 5′-uronamides are selective A₃AR (adenosine receptor) agonists. Here we substitute a 1,2,3-triazol-1-yl linker in place of the rigid, linear ethynyl group to eliminate its potential metabo