Chemical Communications p. 6558 - 6560 (2013)
Update date:2022-08-04
Topics:
Stephens, David
Zhang, Yu
Cormier, Mathew
Chavez, Gabriel
Arman, Hadi
Larionov, Oleg V.
A novel stereospecific three-component reaction of aziridines and azetidines with arynes and acetonitrile has been developed. The reaction affords N-aryl γ-aminobutyronitriles and δ-aminovaleronitriles that can be used as precursors and congeners of a number of bioactive compounds, such as pregabalin and lergotrile.
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