Synthesis of 5-(2-hydroxybenzoyl)-1,3-disubstituted uracils

Article abstract of DOI:10.1055/s-0033-1338932

A new synthesis of novel nucleoside analogues is reported. These 5-(2-hydroxybenzoyl)-1,3-disubstituted uracils have been prepared by the coupling of chromone-3-carboxylic acid with carbodiimides, leading to 3-chromone-N-acylureas, which underwent organocatalyzed N-cyclization and chromone ring opening. In the case of ditolylcarbodiimide, the corresponding uracil was obtained by a one-pot, uncatalyzed reaction with chromone-3- carboxylic acid. Georg Thieme Verlag Stuttgart New York.